Developmental Changes in Parvalbumin Regulate Presynaptic Ca2+ Signaling
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چکیده
منابع مشابه
Developmental changes in parvalbumin regulate presynaptic Ca2+ signaling.
Certain interneurons contain large concentrations of specific Ca2+-binding proteins (CBPs), but consequences on presynaptic Ca2+ signaling are poorly understood. Here we show that expression of the slow CBP parvalbumin (PV) in cerebellar interneurons is cell specific and developmentally regulated, leading to characteristic changes in presynaptic Ca2+ dynamics (Ca(i)). Using whole-cell recording...
متن کاملDevelopmental Changes in Parvalbumin Regulate Presynaptic Ca Signaling
Thibault Collin,1 Mireille Chat,1 Marie Gabrielle Lucas,1 Herman Moreno,2 Peter Racay,3,4 Beat Schwaller,2 Alain Marty,1 and Isabel Llano1 1Laboratory of Cerebral Physiology, Centre National de la Recherche Scientifique, University Paris 5, 75006 Paris, France, 2Gertrude H. Sergievsky and Taub Center for Alzheimer Research, Columbia University, New York, New York 10032, 3Division of Histology, ...
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متن کاملParvalbumin is a mobile presynaptic Ca2+ buffer in the calyx of Held that accelerates the decay of Ca2+ and short-term facilitation.
Presynaptic Ca2+ signaling plays a crucial role in short-term plasticity of synaptic transmission. Here, we studied the role of mobile endogenous presynaptic Ca2+ buffer(s) in modulating paired-pulse facilitation at a large excitatory nerve terminal in the auditory brainstem, the calyx of Held. To do so, we assessed the effect of presynaptic whole-cell recording, which should lead to the diffus...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2005
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3748-04.2005